![]() Based on evidence supporting a role for N-methyl d-aspartate receptors (NMDARs) in cough, we hypothesized that memantine, a low-affinity, uncompetitive NMDAR channel blocker in routine use for the treatment of Alzheimer disease, could be an effective, well-tolerated, antitussive therapy. Saulsberry, Lorenīackground: The treatment of cough is a significant clinical unmet need because there is little evidence that current therapies are effective. Published by Elsevier Inc.Īntitussive Effects of Memantine in Guinea Pigs European Union Clinical Trials Register (EudraCT No.: 2013-004735-68) URL. The results are consistent with a peripheral action by levodropropizine the assessment of ventilatory responses to CO 2 may represent a useful tool to investigate the central respiratory effects of antitussive agents. The ventilatory increases by hypercapnia were mainly accounted for by a rise in the volume components of the breathing pattern. At variance with dihydrocodeine, levodropropizine and placebo did not affect respiratory responses to hypercapnia (P <. ![]() Changes in breathing pattern variables were also assessed. ![]() Fractional end-tidal CO 2 (Fetco 2 ) and inspiratory minute ventilation (VË™i) were continuously monitored. Subsequently, patients breathed a mixture of 93% oxygen and 7% CO 2 for 5 min. On separate runs, each patient was randomly administered 60 mg levodropropizine, 15 mg dihydrocodeine, or a matching placebo. Twenty-four outpatients (aged 39-70 years) with chronic cough were studied. We set out to compare the effects of levodropropizine and the opioid antitussive agent dihydrocodeine on the respiratory responses to a conventional CO 2 rebreathing test in patients with chronic cough of any origin. However, the lack of a central action by levodropropizine remains to be fully established. Levodropropizine is classified as a nonopioid peripherally acting antitussive drug that acts at the level of airway sensory nerves. Mannini, Claudia Lavorini, Federico Zanasi, Alessandro Saibene, Federico Lanata, Luigi Fontana, GiovanniĬough is produced by the same neuronal pool implicated in respiratory rhythm generation, and antitussive drugs acting at the central level, such as opioids, may depress ventilation. A Randomized Clinical Trial Comparing the Effects of Antitussive Agents on Respiratory Center Output in Patients With Chronic Cough.
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